figshare
Browse
gnpl_a_1416379_sm8827.pdf (310.19 kB)

A new abietane diterpenoid from the roots of Tripterygium regelii

Download (310.19 kB)
journal contribution
posted on 2017-12-20, 05:38 authored by Zhi-Hua Jiang, Yan-Ping Liu, Miao He, Jin-Hua Zhao, Ting-Ting Wang, Xing-Yang Feng, Hao Yue, Ren-Bo An, Yan-Hui Fu

A new abietane diterpenoid, tripterregeline A (1), together with six known diterpenoids (27), were isolated from the roots of Tripterygium regelii. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 17 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.58 to 21.06 μM.

History