A new 3-alkylpyridine alkaloid from the marine sponge <i>Haliclona</i> sp. and its cytotoxic activity

<p>A new alkaloid, 3-dodecyl pyridine containing a terminal cyano group (<b>1</b>), was isolated from the methanol extract of an Indonesia marine sponge <i>Haliclona</i> sp. Its chemical structure was determined by a combination of spectroscopic methods, including 1D and 2D NMR. Bioassay results indicated that compound <b>1</b> had moderate cytotoxity against tumour cell lines A549, MCF-7 and Hela with IC<sub>50</sub> values of 41.8, 48.4 and 33.2 μM, respectively.</p>