A new12-membered lactone from the stems of <i>Ficus auriculata</i>

<p>A new lactone ficusine D (<b>1</b>), together with six known compounds (<b>2</b>–<b>7</b>) were isolated from the stems of the <i>Ficus auriculata</i>. The new compound <b>1</b> was a rare 12-membered lactone containing a quinone ring skeleton. The structure of the <b>1</b> was elucidated by comprehensive spectroscopic data. The relative and absolute configurations of <b>1</b> were elucidated by the ROESY analysis and biogenesis pathway. All compounds were evaluated for their antibacterial activities against six pathogenic bacteria <i>in vitro</i>. Compounds <b>6</b> and <b>7</b> exhibited potent antibacterial activities against <i>Bacillus cereus</i> with the MIC values of 2.5 and 5 μM, respectively.</p>