Fig 8.TIF (8.23 MB)
A model for key LIC2 functions in SAC silencing during mitosis.
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posted on 2016-07-21, 13:37 authored by Sagar P. Mahale, Amit Sharma, Sivaram V. S. MylavarapuNovel functions of mitotic LIC2 uncovered from this study in silencing the spindle assembly checkpoint (SAC) are shown. LIC2-dynein strips attachment sensing SAC proteins (Mad1, Mad2, Zw10) from metaphase kinetochores, like LIC1-dynein. LIC2-dynein has the additional capability of causing removal of tension-sensing SAC protein BubR1, which is lacking in LIC1-dynein. The model offers a possible mechanistic explanation for the differential effects of the two LICs in mediating metaphase to anaphase progression.
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Keywords
motor cytoplasmic dyneinSACeukaryotic cell divisionDynein Light Intermediate Chain 2 Facilitatescytoplasmic dyneinLIC 1LIC 2tension-sensing checkpoint proteinsLIC 2 depletionkinetochore-microtubule attachment-sensing armhomolog LIC 1.dynein Light Intermediate Chain homologsQuantitative fluorescence microscopyLIC 2 subunitSpindle Assembly Checkpointcytoplasmic dynein complexesmitotic checkpoint inactivationspindle assembly checkpoint
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