figshare
Browse
gsch_a_1266359_sm3067.doc (139 kB)

A facile preparation method for nanosized MOFs as a multifunctional material for cellular imaging and drug delivery

Download (139 kB)
journal contribution
posted on 2016-12-07, 11:37 authored by Kyeng Min Park, Hyunuk Kim, James Murray, Jaehyoung Koo, Kimoon Kim

Tb-based metal-organic framework nanoparticles (Tb-MOF NPs) with good colloidal stability and stable fluorescence properties in an aqueous solution were prepared by a simple mechanical grinding of Tb-MOF with a biocompatible polymer surfactant (F127). The characteristic fluorescence property of Tb-MOF NPs allowed us to use this nanomaterial as a cell imaging probe. Efficient cellular uptake of Tb-MOF NPs apparently via an energy-dependent endocytosis was observed by confocal laser scanning microscopy. By taking advantage of the porous nature of the Tb-MOF NPs an anticancer drug (doxorubicin) was successfully loaded and delivered to kill cancer cells to demonstrate their usage as a drug delivery vehicle. This simple grinding method afforded a nanosized, multifunctional biomaterial that was used for cell imaging and drug delivery, and it can be extended to other MOFs to widen their applications.

History