Facile expeditious one-pot synthesis and antifungal evaluation of disubstituted 1,2,3-triazole with two amide linkages

2017-11-08T15:05:42Z (GMT) by C. P. Kaushik Raj Luxmi
<p>A library of twenty five amide linked 1,4-disubstituted 1,2,3-triazoles have been prepared through a facile expeditious synthetic protocol involving Cu(I) mediated cyclization of <i>N</i>-(2-methylbut-3-yn-2-yl)aromatic amides and <i>in situ</i> generated 2-azido-<i>N</i>-substituted propanamides. Structures of newly synthesized compounds (<b>5a</b>–<b>5y</b>) were confirmed by analytical techniques, such as FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS. <i>In vitro</i> antifungal activity was also examined against two fungal strains <i>Candida albicans</i> and <i>Aspergillus niger</i> by serial dilution method. The compounds <b>5 m</b> and <b>5w</b> exhibited appreciable potent activity.</p>