A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam.

Wang, Ya-Li; Zhao, Jian-Chao; Liang, Jia-Hao; Tian, Xiang-Ge; Huo, Xiao-Kui; Feng, Lei; Ning, Jing; Wang, Chao; Zhang, Bao-Jing; Chen, Gang; Li, Ning; Sun, Cheng-Peng

doi:10.6084/m9.figshare.5644027.v1

gnpl_a_1408106_sm6120.pdf (1.52 MB)

A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam.

journal contribution

posted on 2017-11-29, 06:56 authored by Ya-Li Wang, Jian-Chao Zhao, Jia-Hao Liang, Xiang-Ge Tian, Xiao-Kui Huo, Lei Feng, Jing Ning, Chao Wang, Bao-Jing Zhang, Gang Chen, Ning Li, Cheng-Peng Sun

A new protostane-type triterpenoid, 5β,29-dihydroxy alisol A (1) was isolated from Alisma plantago-aquatica subsp. orientale (Sam.) Sam. as well as 12-deoxyphorbol-13α-pentadecanoate (2). We first report the presence of compound 2 in the genus Alisma. Their structures were established on the basis of 1D and 2D NMR, and HRESIMS spectroscopic analyses. All the isolated compounds were assayed for their inhibitory effects against human carboxylesterase 2 (HCE-2). Compounds 1 and 2 displayed inhibitory activities against HCE-2 with IC₅₀ values of 29.2 and 4.6 μM, respectively. The interaction mechanisms of HCE-2 with compounds 1 and 2 were investigated by molecular docking, respectively.