A Versatile Approach to PI(3,4)P<sub>2</sub>, PI(4,5)P<sub>2</sub>, and PI(3,4,5)P<sub>3</sub> from l-(−)-Quebrachitol

A versatile synthesis of PI(3,4)P<sub>2</sub>, PI(4,5)P<sub>2</sub>, and PI(3,4,5)P<sub>3</sub> is disclosed, starting from l-(−)-quebrachitol, a byproduct of latex production. The crystalline nature of most intermediates and the utilization of inexpensive protecting groups facilitate this synthetic route and its scale-up.