A Versatile Approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from l-(−)-Quebrachitol

A versatile synthesis of PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 is disclosed, starting from l-(−)-quebrachitol, a byproduct of latex production. The crystalline nature of most intermediates and the utilization of inexpensive protecting groups facilitate this synthetic route and its scale-up.