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SI2:SSE: Collaborative Research: Integrated Tools for DNA Nanostructure Design and Simulation

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posted on 05.02.2020 by Tural Aksel, Nick Fong, Christopher Maffeo, Himanshu Joshi, Aleksei Aksimentiev, Shawn Douglas
While the robustness of the DNA origami method has enabled researchers to fabricate a large diversity of shapes, many design choices are made according to ad hoc rules and heuristics derived from limited empirical data. It would be beneficial to establish a quantitative physical basis for favoring one strand routing over another for a given shape. We have developed Cadnano Toolkit (CTK) and Molecular Dynamics Simulations of Self-Assembled DNA Nanostructures (MrDNA), a suite of programs to augment several aspects of the DNA origami design process.

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SI2-SSE: Collaborative Research: Integrated Tools for DNA Nanostructure Design and Simulation

Directorate for Computer & Information Science & Engineering

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