cg0341609_si_002.cif (135.88 kB)
A Systematic Study of the Relationship between Molecular and Crystal Structure among 3,5-Diazabicyclo[2.2.2]octane-2,6-diones
dataset
posted on 2004-05-05, 00:00 authored by Jason T. Brewer, Sean Parkin, Robert B. GrossmanA simple, convergent synthesis of 3,5-diazabicyclo[2.2.2]octane-2,6-diones (bicyclic N,N‘-diacylaminals)
has been developed, providing access to a large series of compounds differing only in their substituents at the
bridgehead positions. These compounds crystallize in several different forms, but always in such a way that each
molecule forms four hydrogen bonds. The sheer number of bicyclic amidals that can be synthesized and crystallized
provides an opportunity to elucidate crystal-engineering structure−structure relationship (SSR) principles.