lsyc_a_1189574_sm8684.docx (1020.78 kB)
New synthesis route for the preparation of pomalidomide
Version 2 2016-08-03, 02:18
Version 1 2016-05-24, 07:53
journal contribution
posted on 2016-08-03, 02:18 authored by Daowei Huang, Chengwu Shen, Wenya Wang, Lei Huang, Feng Ni, Jianqi LiA new route for the preparation of pomalidomide is described in the study. The synthetic procedure starts from 4-nitroisobenzofuran-1,3-dione and 3-aminopiperidine-2,6-dione hydrochloride via a three-step reaction resulting in a total yield of 65% with a high-performance liquid chromatographic (HPLC) purity of 99.56% and a low palladium residue level of 2 ppm. This method can be deemed as an efficient, practical, and environmentally friendly synthetic route for the preparation of pomalidomide.