A New Class of Chiral Pyrrolidine−Pyridine Conjugate Base Catalysts for Use
in Asymmetric Michael Addition Reactions

Ishii, Takaaki; Fujioka, Shingo; Sekiguchi, Yusuke; Kotsuki, Hiyoshizo

doi:10.1021/ja046871g.s001

ja046871g_si_001.pdf (7.54 MB)

A New Class of Chiral Pyrrolidine−Pyridine Conjugate Base Catalysts for Use in Asymmetric Michael Addition Reactions

journal contribution

posted on 2004-08-11, 00:00 authored by Takaaki Ishii, Shingo Fujioka, Yusuke Sekiguchi, Hiyoshizo Kotsuki

Direct catalytic asymmetric Michael addition reactions of ketones to nitroolefins using newly developed chiral pyrrolidine−pyridine conjugate bases as catalysts are described. The desired 1,4-adducts are obtained in excellent yields with high enantio- and diastereoselectivities.