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A Nanoscale Multichannel Closed Bipolar Electrode Array for Electrochemiluminescence Sensing Platform
journal contribution
posted on 2016-01-05, 00:00 authored by Qingfeng Zhai, Xiaowei Zhang, Yanchao Han, Junfeng Zhai, Jing Li, Erkang WangIn this work, we report a nanoscale
multichannel closed bipolar electrode (BPE) array based on the poly(ethylene
terephthalate) (PET) membrane for the first time. With our design,
oxidants, coreactants, quenchers, and even biomarkers can be detected
in a Ru(bpy)32+/TPA (tripropylamine) electrochemiluminescence
(ECL) system. The multichannel PET membrane was etched according to
our desire by NaOH, and then Au nanofibers were decorated in the inner
region of the channel as a BPE array. Using ECL as a signal readout,
a series of targets including TPA, Ru(bpy)32+, dopamine, H2O2, alpha-fetoprotein (AFP),
and carcino-embryonic antigen (CEA) can be detected with this device.
The practical application of the proposed multichannel closed BPE
array was verified in the detection of AFP and CEA in human serum
with satisfying results. This kind of nanoscale device holds promising
potential for multianalysis. More importantly, as the PET membrane
used in this device can be etched with a desirable diameter (nano-
to microscale) and different BPE array densities (ion tracks of 108/cm2, 106/cm2, 104/cm2), our design can be served as a useful platform for
future advances in nanoscale bipolar electrochemistry.