A NOVEL HYBRID COMPLEX FORMED FROM THE PIPLARTINE AND VANADIL ION: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY STUDY
The synthesis, characterization and antimicrobial activity of novel vanadium (IV) complex derived of amide natural piplartine is reported. The minimum inhibitory concentrations (MIC) of complex, piplartine and vanadyl sulphate used in the synthesis were determined against six bacteria and one fungus. The complex exhibited good activity with minimal inhibitory concentration values ranging from 156.2 to 625 µg mL-1, it was observed the lowest value for the Escherichia coli bacteria with MIC 156.2 µg mL-1 and Microsporum gypseum fungus with MIC 312.5 µg/mL. In overall, the complex showed better antimicrobial activity than the piplartine. Additionally, the V-PIP complex was completely soluble in water, on the contrary of the piplartine free; which means that the proposal complex consists in a potential candidate to drug.