ja3084434_si_001.cif (18.79 kB)
A Luminescent and Biocompatible PhotoCORM
dataset
posted on 2012-11-07, 00:00 authored by Agustin
E. Pierri, Alessia Pallaoro, Guang Wu, Peter C. FordThe water-soluble rhenium(I) complex fac-[Re(bpy)(CO)3(thp)]+ (1) [CF3SO3– salt; bpy = 2,2′-bipyridine,
thp
= tris(hydroxymethyl)phosphine] is both strongly luminescent and photoactive
toward carbon monoxide release. It is stable in aerated aqueous media,
is incorporated into cells from the human prostatic carcinoma cell
line PPC-1, and shows no apparent cytotoxicity. Furthermore, the solvated
Re(I) photoproduct of CO release (2) is also luminescent,
a feature that allows one to track the transformation of 1 to 2 inside such cells using confocal fluorescence
microscopy. In this context, 1 is a very promising candidate
as a photoactivated CO releasing moiety (photoCORM) with potential
therapeutic applications.