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A Luminescent Amine-Functionalized Metal–Organic Framework Conjugated with Folic Acid as a Targeted Biocompatible pH-Responsive Nanocarrier for Apoptosis Induction in Breast Cancer Cells
Version 2 2023-07-24, 11:04
Version 1 2019-11-25, 17:33
journal contribution
posted on 2023-07-24, 11:04 authored by Reza Abazari, Farangis Ataei, Ali Morsali, Alexandra M. Z. Slawin, Cameron L. Carpenter-WarrenFolic acid amine-functionalized metal–organic
framework
(FOLA@NH2-Eu:TMU-62) with luminescent properties loaded
with 5-fluorouracil (5-Fu), as an anticancer medication, was used
to construct a new cancer targeted drug delivery system in the present
study. The 5-Fu release from this targeted carrier along with MTT
assay and trypan blue dye exclusion test results also exhibited pH-controlled
characteristics of the given carrier in acidic environments, which
is very suitable for targeting solid tumors. Then, the inhibitory
action of 5-Fu-loaded FOLA@NH2-Eu:TMU-62 for Michigan Cancer
Foundation-7 (MCF7) cell migration was explored according to scratch
wound healing assays. Based on the results, the FOLA@NH2-Eu:TMU-62 carrier was not toxic for MCF-10A normal cells, but it
was significantly toxic for MCF-7 breast cancer ones, revealing that
the FOLA@NH2-Eu:TMU-62 carrier could be utilized in accurate
cancer treatments through apoptotic pathways with higher reactive
oxygen species compared with 5-Fu alone. This cancer-targeted design
of FOLA@NH2-Eu:TMU-62 could thus pave the way for synergistic
effects of targeting as well as organized release capabilities.
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10a normal cellstargeted biocompatible phorganized release capabilitiesmichigan cancer foundationaccurate cancer treatmentstargeted carrier alongtargeting solid tumorsluminescent properties loaded62 carrier couldtargeted designluminescent aminegiven carrier62 carrierfu releasesynergistic effectsresponsive nanocarrierpresent studymtt assayloaded folainhibitory actionfolic acidexplored accordingcontrolled characteristicscell migrationapoptotic pathwaysapoptosis inductionanticancer medicationacidic environments
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