jo071029p_si_002.pdf (4 MB)
A Chelation-Assisted Transformation: Synthesis of Maleimides by the Rh-Catalyzed Carbonylation of Alkynes with Pyridin-2-ylmethylamine
journal contribution
posted on 2007-08-17, 00:00 authored by Satoshi Inoue, Yoshiya Fukumoto, Naoto ChataniThe reaction of alkynes 1 with CO and pyridin-2-ylmethylamine (2) in the presence of Rh4(CO)12/P(OEt)3 results in
the incorporation of two molecules of CO leading to
maleimide derivatives 3. The coordination of the pyridine
nitrogen in 2 to a rhodium center is essential for the reaction
to proceed.