ol990526s_si_001.pdf (69.19 kB)
A Caged Hydrophobic Inhibitor of Carbonic Anhydrase II
journal contribution
posted on 1999-06-04, 00:00 authored by Polina D. Kehayova, Gregory E. Bokinsky, John D. Huber, Ahamindra JainA tight-binding, hydrophobic inhibitor of carbonic anhydrase II has been masked with a water-solubilizing, photolabile group derived from
o-nitrophenylglycine. This caged inhibitor represents our first effort at the site-specific delivery of prodrugs that can be activated by light. Via
this approach, we have begun to address the problems of water insolubility and systemic side effects on administration of tight-binding
inhibitors of carbonic anhydrase.