Hypolipidaemic and antioxidant properties of ethanol extract from <i>Flos populi</i> Yan Zhao Guosheng Tang Enbo Cai Shuangli Liu Lianxue Zhang Shijie Wang 10.6084/m9.figshare.997775.v3 https://tandf.figshare.com/articles/journal_contribution/Hypolipidaemic_and_antioxidant_properties_of_ethanol_extract_from_i_Flos_populi_i_/997775 <div><p>This study was undertaken to evaluate antihyperlipidaemic and <i>in vitro</i> antioxidant activity of ethanolic extract of <i>Flos populi</i> (EFP). The results demonstrated that EFP contains 78.5% flavonoids and 10.4% phenolics, and it exhibited free radical-scavenging activity on 2,2-diphenyl-picrylhydrazyl (IC<sub>50</sub> 36.40 ± 0.62 μg/mL) and high reducing power (EC<sub>50</sub> 206.32 ± 1.6l μg/mL) under <i>in vitro</i> chemical assays. And irrespective of prophylactic administration or remedial administration, in high fat diet-induced hyperlipidaemic mice, oral treatment with EFP produced a decrease in the levels of serum total cholesterol, triglycerides, low-density lipoprotein-cholesterol and increase in high-density lipoprotein-cholesterol. In a word, in high fat diet-fed hyperlipidaemic mice, EFP (100, 200 and 400 mg/kg) significantly altered the plasma lipid levels to near normal. These results support a potential effect of EFP in cardiovascular disease.</p></div> 2014-08-18 13:17:44 hypolipidaemic antioxidant ethanol extract