10.6084/m9.figshare.997774.v2 Gamal A. Mohamed Gamal A. Mohamed Ali E.E. Abd-Elrazek Ali E.E. Abd-Elrazek Hashim A. Hassanean Hashim A. Hassanean Abdulrahman M. Alahdal Abdulrahman M. Alahdal Ameen Almohammadi Ameen Almohammadi Diaa T.A. Youssef Diaa T.A. Youssef New fatty acids from the Red Sea sponge <i>Mycale euplectellioides</i> Taylor & Francis Group 2014 fatty acids sponge 2014-06-30 08:25:17 Journal contribution https://tandf.figshare.com/articles/journal_contribution/New_fatty_acids_from_the_Red_Sea_sponge_i_Mycale_euplectellioides_i_/997774 <div><p>Chemical investigation of the Red Sea sponge <i>Mycale euplectellioides</i> afforded two new compounds; hexacosa-(6<i>Z</i>,10<i>Z</i>)-dienoic acid methyl ester (<b>1</b>) and hexacosa-(6<i>Z</i>,10<i>Z</i>)-dienoic acid (<b>2</b>), along with two known compounds: icosa-(8<i>Z</i>,11<i>Z</i>)-dienoic acid methyl ester (<b>3</b>) and β-sitosterol (<b>4</b>). The structures were elucidated by the interpretation of their spectral data. The total methanol extract (TME) of the sponge exhibited potent antimicrobial activity against the different strains at a concentration of 100 mg/mL. All tested fractions did not exhibit any activity against <i>Serratia marcescens</i> and tested fungal strains. The TME and different fractions displayed anti-inflammatory and antipyretic activities at doses of 100 and 200 mg/kg compared with indomethacin (8 mg). The TME exhibited a remarkable hepato-protective effect in CCl<sub>4</sub>-induced liver damage compared with silymarin. Furthermore, compounds <b>1</b> and <b>2</b> displayed weak activity against A549 non-small cell lung cancer, the U373 glioblastoma and the PC-3 prostate cancer cell lines.</p></div>