TY - DATA T1 - Design and Optimization of Ecofriendly One-Pot Synthesis of 2,4,5-Triaryl-1H-imidazoles by Three-Component Condensation Using Response Surface Methodology PY - 2014/06/18 AU - T. Durai Ananda Kumar AU - N. Yamini AU - C. V. S. Subrahmanyam AU - K. Satyanarayana UR - https://tandf.figshare.com/articles/dataset/Design_and_Optimization_of_Ecofriendly_One_Pot_Synthesis_of_2_4_5_Triaryl_1_i_H_i_imidazoles_by_Three_Component_Condensation_Using_Response_Surface_Methodology/985578 DO - 10.6084/m9.figshare.985578.v3 L4 - https://ndownloader.figshare.com/files/1524669 L4 - https://ndownloader.figshare.com/files/1524670 L4 - https://ndownloader.figshare.com/files/1524671 L4 - https://ndownloader.figshare.com/files/1524672 L4 - https://ndownloader.figshare.com/files/1524673 L4 - https://ndownloader.figshare.com/files/1524674 L4 - https://ndownloader.figshare.com/files/1524675 L4 - https://ndownloader.figshare.com/files/1524676 L4 - https://ndownloader.figshare.com/files/1524677 L4 - https://ndownloader.figshare.com/files/1524678 L4 - https://ndownloader.figshare.com/files/1524679 L4 - https://ndownloader.figshare.com/files/1524680 KW - optimization KW - ecofriendly KW - one-pot KW - synthesis KW - three-component KW - condensation KW - methodology N2 - Phase-transfer-catalyzed, highly versatile, and high-yielding protocol for the synthesis of 2,4,5-triaryl-1H-imidazoles was developed through response surface methodology (RSM). The effects of different solvents, reaction paths, and phase-transfer catalysts (PTCs) in different concentrations were envisioned. Three independent variables (catalyst, catalyst loading, and solvent volume) identified by one-factor-at-a-time (OFAT) study were screened through full factorial design at two levels. The analysis of variance results suggested the significance of catalyst PEG400 and solvent glacial acetic acid at 5 h reaction. The optimum reaction conditions suggested by the RSM were the use of PEG400 (10.61 mol%) and glacial acetic acid (10.71 mL) for 5 h cycloocondensation. The experimental yield of 4,5-diphenyl-2-nitrophenyl-1H-imidazole (97%) was in agreement with predicted yield (97.5%). ER -