10.1021/acs.nanolett.9b02483.s001
Cheng Lv
Cheng
Lv
Tian-Yu Zhang
Tian-Yu
Zhang
Yi Lin
Yi
Lin
Man Tang
Man
Tang
Cai-Hua Zhai
Cai-Hua
Zhai
Hou-Fu Xia
Hou-Fu
Xia
Ji Wang
Ji
Wang
Zhi-Ling Zhang
Zhi-Ling
Zhang
Zhi-Xiong Xie
Zhi-Xiong
Xie
Gang Chen
Gang
Chen
Dai-Wen Pang
Dai-Wen
Pang
Transformation of Viral Light Particles into Near-Infrared Fluorescence Quantum Dot-Labeled
Active Tumor-Targeting Nanovectors for Drug Delivery
American Chemical Society
2019
noninfectious L-particles experience
oncolytic virions
tegument proteins
tumor-targeted theranostics nanovector
Near-Infrared Fluorescence Quantum Dot-Labeled
fluorescence Ag 2 Se quantum dot
vivo tumor imaging
progeny virions
tumor-targeting nanovectors
internalization process
ultrasmall water-dispersible NIR fluorescence Ag 2 Se QDs
infection mechanism
electroporation technique
antitumor drug
L-particle-based theranostic platforms
light particles
tumor cells
Such multifunctional nanovectors
Drug Delivery Nanosized oncolytic
Viral Light Particles
antitumor efficacy
loading efficiency
drug delivery
Tumor-Targeting Nanovectors
2019-09-11 18:38:26
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Transformation_of_Viral_Light_Particles_into_Near-Infrared_Fluorescence_Quantum_Dot-Labeled_Active_Tumor-Targeting_Nanovectors_for_Drug_Delivery/9807842
Nanosized oncolytic
viral light particles (L-particles), separated
from progeny virions, are composed of envelopes and several tegument
proteins of viruses, free of nucleocapsids. The noninfectious L-particles
experience the same internalization process as mature oncolytic virions,
which exhibits great potential to act as targeted therapeutic platforms.
However, the clinical applications of L-particle-based theranostic
platforms are rare due to the lack of effective methods to transform
L-particles into nanovectors. Herein, a convenient and mild strategy
has been developed to transform L-particles into near-infrared (NIR)
fluorescence Ag<sub>2</sub>Se quantum dot (QD)-labeled active tumor-targeting
nanovectors for real-time <i>in situ</i> imaging and drug
delivery. Utilizing the electroporation technique, L-particles can
be labeled with ultrasmall water-dispersible NIR fluorescence Ag<sub>2</sub>Se QDs with a labeling efficiency of <i>ca</i>.
85% and loaded with antitumor drug with a loading efficiency of <i>ca</i>. 87%. Meanwhile, by harnessing the infection mechanism
of viruses, viral L-particles are able to recognize and enter tumor
cells without further modification. In sum, a trackable and actively
tumor-targeted theranostics nanovector can be obtained efficiently
and simultaneously. Such multifunctional nanovectors transformed from
viral L-particles have exhibited excellent properties of active tumor-targeting, <i>in vivo</i> tumor imaging, and antitumor efficacy, which opens
a new window for the development of natural therapeutic nanoplatforms.