Schematic depiction of <i>cis</i>- and <i>trans</i>-interactions between E-cadherin ectodomains (ECs) on the cell surface. Dagmar Fichtner Bärbel Lorenz Sinem Engin Christina Deichmann Marieelen Oelkers Andreas Janshoff Andre Menke Doris Wedlich Clemens M. Franz 10.1371/journal.pone.0093123.g001 https://plos.figshare.com/articles/figure/_Schematic_depiction_of_cis_and_trans_interactions_between_E_cadherin_ectodomains_ECs_on_the_cell_surface_/977366 <p><i>Trans</i>-interactions (highlighted in red) are mediated by the EC1 and occur between cadherin molecules of neighboring cells. Lateral <i>cis</i>-interactions (indicated in yellow) occur between the EC1 of one cadherin molecule and the EC2, the EC2/EC3 linker region and part of the EC3 of an adjacent cadherin molecule exposed on the same cell. A combination of <i>cis</i>- and <i>trans</i>-interactions is depicted on the right hand side of the scheme. Here, the EC1 is simultaneously engaged in a <i>cis</i>-interaction with an adjacent cadherin molecule from the same cell, as well as in a <i>trans</i>-interaction with a cadherin molecule from an opposite cell (the EC2 involved in both <i>cis</i>- and <i>trans</i>- interactions is colored in yellow and red). Model based on <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Harrison1" target="_blank">[14]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Bayas2" target="_blank">[57]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Wu3" target="_blank">[58]</a>.</p> 2014-03-27 03:55:26 Biochemistry proteins Protein interactions Recombinant proteins Biomacromolecule-ligand interactions chemical biology cytochemistry biophysics biotechnology Bioengineering Biological systems engineering Biomedical Engineering Biomimetics biomaterials Bionanotechnology cell biology cell adhesion cadherins Cellular structures and organelles Cell membranes Membrane proteins Transmembrane proteins Molecular cell biology chemistry depiction E-cadherin ectodomains