Schematic depiction of <i>cis</i>- and <i>trans</i>-interactions between E-cadherin ectodomains (ECs) on the cell surface.
Dagmar Fichtner
Bärbel Lorenz
Sinem Engin
Christina Deichmann
Marieelen Oelkers
Andreas Janshoff
Andre Menke
Doris Wedlich
Clemens M. Franz
10.1371/journal.pone.0093123.g001
https://plos.figshare.com/articles/figure/_Schematic_depiction_of_cis_and_trans_interactions_between_E_cadherin_ectodomains_ECs_on_the_cell_surface_/977366
<p><i>Trans</i>-interactions (highlighted in red) are mediated by the EC1 and occur between cadherin molecules of neighboring cells. Lateral <i>cis</i>-interactions (indicated in yellow) occur between the EC1 of one cadherin molecule and the EC2, the EC2/EC3 linker region and part of the EC3 of an adjacent cadherin molecule exposed on the same cell. A combination of <i>cis</i>- and <i>trans</i>-interactions is depicted on the right hand side of the scheme. Here, the EC1 is simultaneously engaged in a <i>cis</i>-interaction with an adjacent cadherin molecule from the same cell, as well as in a <i>trans</i>-interaction with a cadherin molecule from an opposite cell (the EC2 involved in both <i>cis</i>- and <i>trans</i>- interactions is colored in yellow and red). Model based on <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Harrison1" target="_blank">[14]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Bayas2" target="_blank">[57]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Wu3" target="_blank">[58]</a>.</p>
2014-03-27 03:55:26
Biochemistry
proteins
Protein interactions
Recombinant proteins
Biomacromolecule-ligand interactions
chemical biology
cytochemistry
biophysics
biotechnology
Bioengineering
Biological systems engineering
Biomedical Engineering
Biomimetics
biomaterials
Bionanotechnology
cell biology
cell adhesion
cadherins
Cellular structures and organelles
Cell membranes
Membrane proteins
Transmembrane proteins
Molecular cell biology
chemistry
depiction
E-cadherin
ectodomains