10.1371/journal.pone.0093123.g001 Dagmar Fichtner Dagmar Fichtner Bärbel Lorenz Bärbel Lorenz Sinem Engin Sinem Engin Christina Deichmann Christina Deichmann Marieelen Oelkers Marieelen Oelkers Andreas Janshoff Andreas Janshoff Andre Menke Andre Menke Doris Wedlich Doris Wedlich Clemens M. Franz Clemens M. Franz Schematic depiction of <i>cis</i>- and <i>trans</i>-interactions between E-cadherin ectodomains (ECs) on the cell surface. Public Library of Science 2014 Biochemistry proteins Protein interactions Recombinant proteins Biomacromolecule-ligand interactions chemical biology cytochemistry biophysics biotechnology Bioengineering Biological systems engineering Biomedical Engineering Biomimetics biomaterials Bionanotechnology cell biology cell adhesion cadherins Cellular structures and organelles Cell membranes Membrane proteins Transmembrane proteins Molecular cell biology chemistry depiction E-cadherin ectodomains 2014-03-27 03:55:26 Figure https://plos.figshare.com/articles/figure/_Schematic_depiction_of_cis_and_trans_interactions_between_E_cadherin_ectodomains_ECs_on_the_cell_surface_/977366 <p><i>Trans</i>-interactions (highlighted in red) are mediated by the EC1 and occur between cadherin molecules of neighboring cells. Lateral <i>cis</i>-interactions (indicated in yellow) occur between the EC1 of one cadherin molecule and the EC2, the EC2/EC3 linker region and part of the EC3 of an adjacent cadherin molecule exposed on the same cell. A combination of <i>cis</i>- and <i>trans</i>-interactions is depicted on the right hand side of the scheme. Here, the EC1 is simultaneously engaged in a <i>cis</i>-interaction with an adjacent cadherin molecule from the same cell, as well as in a <i>trans</i>-interaction with a cadherin molecule from an opposite cell (the EC2 involved in both <i>cis</i>- and <i>trans</i>- interactions is colored in yellow and red). Model based on <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Harrison1" target="_blank">[14]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Bayas2" target="_blank">[57]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093123#pone.0093123-Wu3" target="_blank">[58]</a>.</p>