10.6084/m9.figshare.97678.v1 Salvador J. Diaz-Cano Salvador J. Diaz-Cano PCR-based alternative for diagnosis of immunoglobulin heavy chain gene rearrangement: principles, practice, and polemics figshare 2012 diagnosis gene rearrangement lymph node lymphoma B-cell Molecular Biology Medicine Hematology Cell Biology Cancer 2012-11-17 20:12:56 Journal contribution https://figshare.com/articles/journal_contribution/PCR-based_alternative_for_diagnosis_of_immunoglobulin_heavy_chain_gene_rearrangement_principles_practice_and_polemics/97678 <p>PCR-based detection of immunoglobulin gene rearrangements is a reliable and accurate method which can be utilized as a clinical test if appropriate quality controls are performed (internal, polyclonal and monoclonal, sensitivity and specificity controls) and strict criteria for clonal rearrangements are used to exclude false-positives and false-negatives.</p>