Effect of graded number of MSCs on renal function and morphology after I/R injury.
Jieru Cai
Xiaofang Yu
Rende Xu
Yi Fang
Xiaoqin Qian
Shaopeng Liu
jie Teng
Xiaoqiang Ding
10.1371/journal.pone.0092347.g004
https://plos.figshare.com/articles/figure/_Effect_of_graded_number_of_MSCs_on_renal_function_and_morphology_after_I_R_injury_/963640
<p>(A) In RA group with PBS only, no further increasing Scr level was detected (5.01±0.87 mg/dl) compared with control group (5.22±0.43 mg/dl). (B) In CA group, the Scr level decreased with increased amounts of injected MSCs. However, in RA group, there was a U-type change and the lowest Scr level was obtained with 1×10<sup>5 </sup>MSCs (3.71±0.96 mg/dl), which was significantly lower than that in all groups, including CA group and RA group (P<0.05). (C–D) Histological examination (HE staining, magnification 200×) showed that the most significant morphological improvement was found in RA group (1×10<sup>5</sup>), which was consistent with functional studies. *<i>P</i><0.05, <i>vs</i> CA group (1×10<sup>6</sup>).</p>
2014-03-17 02:45:39
cell biology
Cellular types
Animal cells
stem cells
mesenchymal stem cells
Molecular cell biology
developmental biology
Critical care and emergency medicine
hematology
Nephrology
Renal failure
Acute renal failure
Surgical and invasive medical procedures
Blood and lymphatic system procedures
Stem cell transplantation
transplantation
graded
mscs
renal
morphology