Effect of graded number of MSCs on renal function and morphology after I/R injury. Jieru Cai Xiaofang Yu Rende Xu Yi Fang Xiaoqin Qian Shaopeng Liu jie Teng Xiaoqiang Ding 10.1371/journal.pone.0092347.g004 https://plos.figshare.com/articles/figure/_Effect_of_graded_number_of_MSCs_on_renal_function_and_morphology_after_I_R_injury_/963640 <p>(A) In RA group with PBS only, no further increasing Scr level was detected (5.01±0.87 mg/dl) compared with control group (5.22±0.43 mg/dl). (B) In CA group, the Scr level decreased with increased amounts of injected MSCs. However, in RA group, there was a U-type change and the lowest Scr level was obtained with 1×10<sup>5 </sup>MSCs (3.71±0.96 mg/dl), which was significantly lower than that in all groups, including CA group and RA group (P<0.05). (C–D) Histological examination (HE staining, magnification 200×) showed that the most significant morphological improvement was found in RA group (1×10<sup>5</sup>), which was consistent with functional studies. *<i>P</i><0.05, <i>vs</i> CA group (1×10<sup>6</sup>).</p> 2014-03-17 02:45:39 cell biology Cellular types Animal cells stem cells mesenchymal stem cells Molecular cell biology developmental biology Critical care and emergency medicine hematology Nephrology Renal failure Acute renal failure Surgical and invasive medical procedures Blood and lymphatic system procedures Stem cell transplantation transplantation graded mscs renal morphology