Expression of GRP78 and phosphorylated JNK in human CCA.
Chunhong Feng
Kai He
Chunyan Zhang
Song Su
Bo Li
Yuxiao Li
Chun-Yan Duan
Shaokun Chen
Run Chen
Youping Liu
Hong Li
Mei Wei
Xianming Xia
Rongyang Dai
10.1371/journal.pone.0090388.g008
https://plos.figshare.com/articles/figure/_Expression_of_GRP78_and_phosphorylated_JNK_in_human_CCA_/949294
<p>(A) GRP78 and phosphorylated JNK in human CCA were analyzed using immunohistochemistry. (B) Summary of experimental findings. In human CCA cells, the phosphorylation of eIF2α initiates ATF4 expression, which then induces GRP78 accumulation. GRP78 plays an important role in promoting human CCA cells proliferation and invasion. Suppression of mTOR inhibits eIF2α-induced ATF4 expression, which leads to a decrease in GRP78 levels. JNK blocking decreases GRP78 levels through inhibiting the activity of mTOR. Similarly, PI3K/Akt blocking decreases GRP78 levels through inhibiting the activity of mTOR.</p>
2014-02-28 04:18:45
biophysics
Protein folding
Molecular cell biology
Signal transduction
Signaling cascades
c-Jun N-terminal kinase signaling cascade
Signaling in selected disciplines
Oncogenic signaling
Cellular stress responses
Gastroenterology and hepatology
Gastrointestinal cancers
oncology
Cancers and neoplasms
Gastrointestinal tumors
grp78
phosphorylated
jnk