%0 Figure %A Feng, Chunhong %A He, Kai %A Zhang, Chunyan %A Su, Song %A Li, Bo %A Li, Yuxiao %A Duan, Chun-Yan %A Chen, Shaokun %A Chen, Run %A Liu, Youping %A Li, Hong %A Wei, Mei %A Xia, Xianming %A Dai, Rongyang %D 2014 %T mTOR controls GRP78 synthesis in human cholangiocarcinoma cells. %U https://plos.figshare.com/articles/figure/_mTOR_controls_GRP78_synthesis_in_human_cholangiocarcinoma_cells_/949289 %R 10.1371/journal.pone.0090388.g006 %2 https://ndownloader.figshare.com/files/1404305 %K biophysics %K Protein folding %K Molecular cell biology %K Signal transduction %K Signaling cascades %K c-Jun N-terminal kinase signaling cascade %K Signaling in selected disciplines %K Oncogenic signaling %K Cellular stress responses %K Gastroenterology and hepatology %K Gastrointestinal cancers %K oncology %K Cancers and neoplasms %K Gastrointestinal tumors %K controls %K grp78 %K synthesis %K cholangiocarcinoma %X

(A) After treated with rapamycin (Rap, 20 nM) for indicated time periods, GRP78 in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. (B) After transfected with simTOR for 60 h, GRP78 in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. (C) After treated with salubrinal (Sal, 25 µM) for 30 h with or without rapamycin (Rap, 20 nM) preincubation for 1 h, GRP78 was analyzed using western blot in HepG2 cells. (D) After treated with tunicamycin (Tun, 2.0 µg/ml) for 24 h with or without rapamycin (Rap, 20 nM) preincubation for 1 h, GRP78 in HepG2 cells was analyzed using western blot.

%I PLOS ONE