mTOR controls GRP78 synthesis in human cholangiocarcinoma cells.
Chunhong Feng
Kai He
Chunyan Zhang
Song Su
Bo Li
Yuxiao Li
Chun-Yan Duan
Shaokun Chen
Run Chen
Youping Liu
Hong Li
Mei Wei
Xianming Xia
Rongyang Dai
10.1371/journal.pone.0090388.g006
https://plos.figshare.com/articles/figure/_mTOR_controls_GRP78_synthesis_in_human_cholangiocarcinoma_cells_/949289
<p>(A) After treated with rapamycin (Rap, 20 nM) for indicated time periods, GRP78 in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. (B) After transfected with simTOR for 60 h, GRP78 in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. (C) After treated with salubrinal (Sal, 25 µM) for 30 h with or without rapamycin (Rap, 20 nM) preincubation for 1 h, GRP78 was analyzed using western blot in HepG2 cells. (D) After treated with tunicamycin (Tun, 2.0 µg/ml) for 24 h with or without rapamycin (Rap, 20 nM) preincubation for 1 h, GRP78 in HepG2 cells was analyzed using western blot.</p>
2014-02-28 04:18:45
biophysics
Protein folding
Molecular cell biology
Signal transduction
Signaling cascades
c-Jun N-terminal kinase signaling cascade
Signaling in selected disciplines
Oncogenic signaling
Cellular stress responses
Gastroenterology and hepatology
Gastrointestinal cancers
oncology
Cancers and neoplasms
Gastrointestinal tumors
controls
grp78
synthesis
cholangiocarcinoma