Feng, Chunhong He, Kai Zhang, Chunyan Su, Song Li, Bo Li, Yuxiao Duan, Chun-Yan Chen, Shaokun Chen, Run Liu, Youping Li, Hong Wei, Mei Xia, Xianming Dai, Rongyang JNK promotes the activity of mTOR in human CCA cells. <p>(A) After treated with SP600125 (SP, 20 µM) for indicated time periods, phosphorylated p70S6K in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. Rapamycin (Rap, 20 nM)-treated cholangiocarcinoma cells were used as positive control. (B) After transfected with siJNK for 60 h, phosphorylated p70S6K in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. (C) After treated with SP600125 (SP, 20 µM) for indicated time periods, phosphorylated mTOR in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. (D) After treated with SP600125 (SP, 20 µM) for indicated time periods, phosphorylated Raptor and phosphorylated 4E-BP1 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.</p> biophysics;Protein folding;Molecular cell biology;Signal transduction;Signaling cascades;c-Jun N-terminal kinase signaling cascade;Signaling in selected disciplines;Oncogenic signaling;Cellular stress responses;Gastroenterology and hepatology;Gastrointestinal cancers;oncology;Cancers and neoplasms;Gastrointestinal tumors;mtor;cca 2014-02-28
    https://plos.figshare.com/articles/figure/_JNK_promotes_the_activity_of_mTOR_in_human_CCA_cells_/949287
10.1371/journal.pone.0090388.g005