TY - DATA T1 - Proliferation and apoptosis in the lungs of AMD3100-treated SU5416/chronic hypoxia (SuHx) animals. PY - 2014/02/24 AU - Daniela Farkas AU - Donatas Kraskauskas AU - Jennifer I. Drake AU - Aysar A. Alhussaini AU - Vita Kraskauskiene AU - Harm J. Bogaard AU - Carlyne D. Cool AU - Norbert F. Voelkel AU - Laszlo Farkas UR - https://plos.figshare.com/articles/figure/_Proliferation_and_apoptosis_in_the_lungs_of_AMD3100_treated_SU5416_chronic_hypoxia_SuHx_animals_/943324 DO - 10.1371/journal.pone.0089810.g007 L4 - https://ndownloader.figshare.com/files/1397025 KW - Anatomy and physiology KW - cardiovascular system KW - Circulatory physiology KW - Model organisms KW - Animal models KW - rat KW - Molecular cell biology KW - Cellular types KW - Endothelial cells KW - cardiovascular KW - Pulmonary vascular diseases KW - Vascular biology KW - apoptosis KW - lungs KW - amd3100-treated KW - hypoxia N2 - (A) Representative Western blot for proliferating cell nuclear antigen (PCNA) and cleaved caspase-3 in the lung tissue protein lysate of naïve control animals (n = 3), SuHx + vehicle (n = 6) and SuHx + AMD3100 treated rats (n = 6). β-actin was used as loading control. (B-C) Densitometric analysis indicates increased PCNA (B) and cleaved caspase-3 (C) protein levels in the lungs of SuHx + vehicle animals vs. controls, and that AMD3100 treatment significantly reduced PCNA and cleaved caspase-3 protein levels in the lungs of SuHx animals. Densitometric values were normalized vs. β-actin and expressed as n-fold of naïve controls. n = 3 animals per group for controls and n = 6 animals per group for SuHx + vehicle and SuHx + AMD3100 groups. * P<0.05 and ** P<0.01. ER -