Snyder, Jason A. Cameron, Heather Brewer, Michelle Pickel, Jim Grigereit, Laura A transgenic rat model for reducing adult neurogenesis <p>The function of adult neurogenesis remains unclear. While many tools for manipulating neurogenesis have been developed for mice, there are fewer tools for rats. Radiological and chemical strategies have been used to inhibit adult neurogenesis in rats but these methods may also have undesired side effects. Since rats have a larger brain and can perform complex behaviors, it would be useful to have additional rat models for studying neurogenesis. To address this gap we therefore developed a transgenic GFAP-TK rat in which adult neurogenesis can be specifically inhibited. Preliminary results suggest that, as in mice, reduced adult neurogenesis leads to anhedonia.</p> adult neurogenesis;open field;olfactory bulb;GFAP thymidine kinase;valganciclovir;novelty-suppressed feeding;dentate gyrus;sucrose preference test;Neuroscience;Behavioral Neuroscience 2012-07-20
    https://figshare.com/articles/poster/A_transgenic_rat_model_for_reducing_adult_neurogenesis/93088
10.6084/m9.figshare.93088.v1