Edg-1 is involved in RTEF-1 driven angiogenesis in endothelial cells.
Ping He
Melissa J. Philbrick
Xiaojin An
Jiaping Wu
Angela F. Messmer-Blust
Jian Li
10.1371/journal.pone.0088143.g003
https://plos.figshare.com/articles/figure/_Edg_1_is_involved_in_RTEF_1_driven_angiogenesis_in_endothelial_cells_/929323
<p><b>A.</b> Edg-1 expression was knocked down by Edg-1 siRNA. (** = <i>p</i><0.01, <i>vs</i> control siRNA treated RTEF-1 o/e HMEC-1) <b>B.</b> Edg-1 siRNA inhibited RTEF-1 driven endothelial cell aggregation. (# = <i>p</i><0.05, <i>vs</i> negative control siRNA treated control HMEC-1; ** = <i>p</i><0.01, <i>vs</i> negative control siRNA treated RTEF-1 o/e HMEC-1; ## = <i>p</i><0.01, <i>vs</i> negative control siRNA treated control HMEC-1; Triangle: aggregation area; Arrow: branch) <b>C.</b> Edg-1 siRNA inhibited RTEF-1 driven endothelial cell migration. (# = <i>p</i><0.05, <i>vs</i> negative control siRNA treated control HMEC-1; * = <i>p</i><0.05, <i>vs</i> negative control siRNA treated RTEF-1 o/e HMEC-1) <b>D.</b> Treatment with Edg-1 siRNA attenuated cell growth in RTEF-1 o/e HMEC-1 (* = <i>p</i><0.05; ** = <i>p</i><0.01, <i>vs</i> negative control siRNA). The results were quantified based on three experiments and are presented as mean±S.D.</p>
2014-02-10 03:22:39
genetics
gene expression
Gene function
Molecular cell biology
DNA transcription
RNA interference
Signal transduction
Signaling in cellular processes
G-protein signaling
Cell growth
cardiovascular
Vascular biology
rtef-1
driven
angiogenesis
endothelial