C. B. da Costa, Emmerson Amorim, Raquel C. da Silva, Fernando R. Rocha, David P. Papa, Michelle B. de Arruda, Luciana Mohana-Borges, Ronaldo Ferreira, Vitor F. Tanuri, Amilcar J. da Costa, Luciana Ferreira, Sabrina B. General scheme used for preparation of pyran naphthoquinones. <p>The o-QM intermediate is generated in situ by Knoevenagel condensation of 2-hydroxy-1,4-naphthoquinone (7) with formaldehyde and arylaldehydes. The subsequent hetero Diels-Alder reaction with substituted dienophiles in aqueous ethanol media yields high amounts of α- and β-lapachone derivatives.</p> pyran 2013-12-20
    https://plos.figshare.com/articles/figure/_General_scheme_used_for_preparation_of_pyran_naphthoquinones_/883656
10.1371/journal.pone.0082504.g002