%0 Figure %A J. Kerkhoven, Eduard %A Achcar, Fiona %A Alibu, Vincent P. %A J. Burchmore, Richard %A Gilbert, Ian H. %A Trybiło, Maciej %A N. Driessen, Nicole %A Gilbert, David %A Breitling, Rainer %A M. Bakker, Barbara %A Barrett, Michael P. %D 2013 %T Phosphate leak in model with PPP. %U https://plos.figshare.com/articles/figure/Phosphate_leak_in_model_with_PPP_/869001 %R 10.1371/journal.pcbi.1003371.g002 %2 https://ndownloader.figshare.com/files/1304048 %K leak %X

Time course simulation of model B, in which the reactions of the glycosomal PPP are switched on at t = 0 by increasing their Vmax value from zero to the value given in Table S1. Glce is 5 mM and kTOX = 2 µl·min−1·mg protein−1. Solid lines indicate medians, shaded areas show interquartile ranges. Fluxes (J) are plotted on the left y-axis and are indicative of glucose uptake (GlcTplasma membrane), glycerol (GK) and pyruvate production (PyrT) and the two branches of pentose phosphate pathways (G6PDHc/g). The sum of bound phosphates in the glycosome (ΣPg), as exists in the model of glycolysis (Table 2, moiety 5), is plotted on the right y-axis. Within 25 minutes, all bound phosphates within the glycosome are depleted and all metabolic fluxes subsequently drop to zero.

%I PLOS Computational Biology