K. Walker, Adam Y. Soo, Kai Sundaramoorthy, Vinod Parakh, Sonam Ma, Yi A. Farg, Manal H. Wallace, Robyn Crouch, Peter J. J. Turner, Bradley K. Horne, Malcolm D. Atkin, Julie Video S1 - ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation <p><b>Association of 218–414 TDP-43-mCherry inclusions with the Golgi apparatus.</b> Neuro2a cells were transfected with the 218–414 TDP-43-mCherry construct, and treated with 10 µM MG132 for 24 h starting at 24 h post-transfection. Cells were processed for immunocytochemistry against GM130 (green) and serial z-stack images were taken at 0.50 µm intervals using confocal microscopy and post-processed using Olympus Fluoview v2.0 software. mCherry fluorescence is shown in red and nuclei (Hoechst dye) are shown in blue. Scale bar represents 10 µm.</p> <p>(MOV)</p> tdp-43;endoplasmic;reticulum;drives;cytoplasmic;accumulation;granule 2013-11-29
    https://plos.figshare.com/articles/media/_ALS_Associated_TDP_43_Induces_Endoplasmic_Reticulum_Stress_Which_Drives_Cytoplasmic_TDP_43_Accumulation_and_Stress_Granule_Formation_/865482
10.1371/journal.pone.0081170.s001