Schematic drawing of brain-bone marrow axis in chronic psychological stress conditions. Koji Ataka Akihiro Asakawa Kanna Nagaishi Kaori Kaimoto Atsushi Sawada Yuko Hayakawa Ryota Tatezawa Akio Inui Mineko Fujimiya 10.1371/journal.pone.0081744.g006 https://plos.figshare.com/articles/figure/_Schematic_drawing_of_brain_bone_marrow_axis_in_chronic_psychological_stress_conditions_/862480 <p>When brain is exposed to chronic PS (1), the information is mediated to bone marrow through adrenergic nerves (2). Bone marrow niche cells innervated with sympathetic nerves decrease the expression of SDF-1 through β<sub>3</sub>-adrenergic receptor (3). CXCR4<sup>high</sup> monocytes egress to peripheral circulation from the bone marrow by reduction of SDF-1 at the bone marrow niche (4). Neurons in the PVN express MCP-1 under chronic PS condition, then accelerate infiltration of CCR2<sup>+</sup> bone marrow-derived microglia into PVN (5).</p> 2013-11-26 03:18:39 brain-bone marrow axis