10.1371/journal.pone.0081744.g006 Koji Ataka Koji Ataka Akihiro Asakawa Akihiro Asakawa Kanna Nagaishi Kanna Nagaishi Kaori Kaimoto Kaori Kaimoto Atsushi Sawada Atsushi Sawada Yuko Hayakawa Yuko Hayakawa Ryota Tatezawa Ryota Tatezawa Akio Inui Akio Inui Mineko Fujimiya Mineko Fujimiya Schematic drawing of brain-bone marrow axis in chronic psychological stress conditions. Public Library of Science 2013 brain-bone marrow axis 2013-11-26 03:18:39 Figure https://plos.figshare.com/articles/figure/_Schematic_drawing_of_brain_bone_marrow_axis_in_chronic_psychological_stress_conditions_/862480 <p>When brain is exposed to chronic PS (1), the information is mediated to bone marrow through adrenergic nerves (2). Bone marrow niche cells innervated with sympathetic nerves decrease the expression of SDF-1 through β<sub>3</sub>-adrenergic receptor (3). CXCR4<sup>high</sup> monocytes egress to peripheral circulation from the bone marrow by reduction of SDF-1 at the bone marrow niche (4). Neurons in the PVN express MCP-1 under chronic PS condition, then accelerate infiltration of CCR2<sup>+</sup> bone marrow-derived microglia into PVN (5).</p>