10.1371/journal.pone.0081744.g006
Koji Ataka
Koji
Ataka
Akihiro Asakawa
Akihiro
Asakawa
Kanna Nagaishi
Kanna
Nagaishi
Kaori Kaimoto
Kaori
Kaimoto
Atsushi Sawada
Atsushi
Sawada
Yuko Hayakawa
Yuko
Hayakawa
Ryota Tatezawa
Ryota
Tatezawa
Akio Inui
Akio
Inui
Mineko Fujimiya
Mineko
Fujimiya
Schematic drawing of brain-bone marrow axis in chronic psychological stress conditions.
Public Library of Science
2013
brain-bone
marrow
axis
2013-11-26 03:18:39
Figure
https://plos.figshare.com/articles/figure/_Schematic_drawing_of_brain_bone_marrow_axis_in_chronic_psychological_stress_conditions_/862480
<p>When brain is exposed to chronic PS (1), the information is mediated to bone marrow through adrenergic nerves (2). Bone marrow niche cells innervated with sympathetic nerves decrease the expression of SDF-1 through β<sub>3</sub>-adrenergic receptor (3). CXCR4<sup>high</sup> monocytes egress to peripheral circulation from the bone marrow by reduction of SDF-1 at the bone marrow niche (4). Neurons in the PVN express MCP-1 under chronic PS condition, then accelerate infiltration of CCR2<sup>+</sup> bone marrow-derived microglia into PVN (5).</p>