The effects of oxytocin (OT) and oxytocin extended form (OT-GKR) on intracellular calcium levels measured in Fura-2-loaded H9c2 cells.
Marek Jankowski
Bogdan A. Danalache
Eric Plante
Ahmed Menaouar
Maria Florian
Ju Jing Tan
Ryszard Grygorczyk
Tom L. Broderick
Jolanta Gutkowska
10.1371/journal.pone.0219205.g006
https://plos.figshare.com/articles/figure/The_effects_of_oxytocin_OT_and_oxytocin_extended_form_OT-GKR_on_intracellular_calcium_levels_measured_in_Fura-2-loaded_H9c2_cells_/8614562
<p>(A). Percentage of calcium-responsive cells counted per microscopic field after treatment with equimolar concentrations (10<sup>−6</sup> M) of OT and OT-GKR. (B) Kinetics of intracellular calcium levels normalized as the F340/F380 ratio in cells responding to OT-GKR and (C) in cells resistant to OT-GKR Data were obtained from 7 separate experiments. For (A), statistical analysis was performed using a Students t-test. Data are presented as mean ± SEM. ***: p<0.001, compared to OT-GKR-treated cells.</p>
2019-07-03 17:37:01
OT-GKR
V 2
OT biosynthetic precursor forms
OT-GK
CHO cells overexpressing V 2 receptor
EC
AVP
diuresi
sodium excretion
OTA
receptor V 2
V 2 R antagonist
V 2 R
OT-G
OTR