TY - DATA T1 - Role of periostin in inducing inflammatory responses in vivo. PY - 2013/11/19 AU - Osamu Yamashita AU - Koichi Yoshimura AU - Ayako Nagasawa AU - Koshiro Ueda AU - Noriyasu Morikage AU - Yasuhiro Ikeda AU - Kimikazu Hamano UR - https://plos.figshare.com/articles/figure/_Role_of_periostin_in_inducing_inflammatory_responses_in_vivo_/856523 DO - 10.1371/journal.pone.0079753.g006 L4 - https://ndownloader.figshare.com/files/1288090 KW - periostin KW - inducing KW - inflammatory KW - responses N2 - A-B: Gelfoam patches containing PBS (Control, n = 6) or recombinant periostin (rPeriostin, n = 7) were placed into periaortic spaces of mice for 7 days. Representative images show mouse aortic walls, stained with hematoxylin/eosin (HE) or with antibodies against periostin, phosphorylated FAK (pFAK), or MCP-1 (A). Infiltrating cells were counted in 5-10 high-power fields (B). Data are mean ± SE. *p<0.05 compared to Control. C: Schematic diagram represents the proposed vicious cycle of periostin upregulation driven by mechanical strain through activation of FAK, resulting in the maintenance of inflammation in AAA. ER -