TY - DATA T1 - Impact of myriocin and antifungal drugs on phenoloxidase (PO) activity during Candida albicans pathogenesis. PY - 2013/11/15 AU - Nadja Rodrigues de Melo AU - Ahmed Abdrahman AU - Carolyn Greig AU - Krishnendu Mukherjee AU - Catherine Thornton AU - Norman A. Ratcliffe AU - Andreas Vilcinskas AU - Tariq M. Butt UR - https://plos.figshare.com/articles/figure/_Impact_of_myriocin_and_antifungal_drugs_on_phenoloxidase_PO_activity_during_Candida_albicans_pathogenesis_/853251 DO - 10.1371/journal.pone.0078905.g005 L4 - https://ndownloader.figshare.com/files/1284010 KW - myriocin KW - antifungal KW - drugs KW - phenoloxidase N2 - The in vitro PO activity of G. mellonella larval hemolymph was measured at 24 h during fungal pathogenesis and drug treatments. Significant decreases of PO activity were detected in the groups treated with AMPH and MYR+FLC (*p<0.001, n = 10) when compared with the controls. In addition, all the treatments in which Candida was present, a significant decrease of PO activity was observed when compared with the control groups (**p<0.001, n = 10). However larvae from MYR+CA group showed higher PO activity (§ p<0.05) when compared with CA group alone. Controls were uninjected (CT) or PBS injected larvae. The drug treatments and abbreviations are as in Figure 1. Error bars indicate standard errors. Each experiment was triplicated. ER -