Bacterial replication in lungs and spleen of BALB/c mice vaccinated with MGM1991, or BCG and challenged with 10<sup>5</sup> CFU of virulent luminescent <i>M. tuberculosis</i>. Dorsaf Hedhli Olivier Denis Daniel Barkan Mamadou Daffé Michael S. Glickman Kris Huygen 10.1371/journal.pone.0076442.g007 https://plos.figshare.com/articles/figure/_Bacterial_replication_in_lungs_and_spleen_of_BALB_c_mice_vaccinated_with_MGM1991_or_BCG_and_challenged_with_10_5_CFU_of_virulent_luminescent_M_tuberculosis_/826894 <p>Mean number of bacteria in lungs and spleen of C57BL/6 mice vaccinated with 5x10<sup>5</sup>CFU of MGM1991 mutant or BCG or unvaccinated mice (naïve), challenged 12 weeks later with 10<sup>5</sup>CFU of virulent <i>M.tb</i> by the intratracheal route and sacrificed 6 or 12 weeks after challenge. Results are reported as mean log<sub>10</sub> relative light units (RLU) ± SD of 5 mice tested individually; * <i>P</i> < 0.05; ** <i>P</i> < 0.01 (Mann-Whitney test).</p> 2013-10-17 04:37:21 replication lungs spleen mice vaccinated bcg challenged cfu virulent luminescent