Table_2_Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment.XLSX
Fabiola Lilí Sarmiento-Salinas
Alam Delgado-Magallón
José Benito Montes-Alvarado
Dalia Ramírez-Ramírez
Juan Carlos Flores-Alonso
Paulina Cortés-Hernández
Julio Reyes-Leyva
Irma Herrera-Camacho
Maricruz Anaya-Ruiz
Rosana Pelayo
Lourdes Millán-Pérez-Peña
Paola Maycotte
10.3389/fonc.2019.00480.s006
https://frontiersin.figshare.com/articles/dataset/Table_2_Breast_Cancer_Subtypes_Present_a_Differential_Production_of_Reactive_Oxygen_Species_ROS_and_Susceptibility_to_Antioxidant_Treatment_XLSX/8242799
<p>Due to their crucial role in cell metabolism and homeostasis, alterations in mitochondrial biology and function have been related to the progression of diverse diseases including cancer. One of the consequences associated to mitochondrial dysfunction is the production of reactive oxygen species (ROS). ROS are known to have a controversial role during cancer initiation and progression and although several studies have tried to manipulate intracellular ROS levels using antioxidants or pro-oxidation conditions, it is not yet clear how to target oxidation for cancer therapy. In this study, we found differences in mitochondrial morphology in breast cancer cells when compared to a non-tumorigenic cell line and differences in mitochondrial function among breast cancer subtypes when exploring gene-expression data from the TCGA tumor dataset. Interestingly, we found increased ROS levels in triple negative breast cancer (TNBC) cell lines and a dependency on ROS for survival since antioxidant treatment induced cell death in TNBC cells but not in an estrogen receptor positive (ER+) cell line. Moreover, we identified the mitochondria as the main source of ROS in TNBC cell lines. Our results indicate a potential use for ROS as a target for therapy in the TNBC subtype which currently has the worst prognosis among all breast cancers and remains as the only breast cancer subtype which lacks a targeted therapy.</p>
2019-06-07 14:26:56
breast cancer
ROS
mitochondria
mitochondrial morphology
mitochondrial ROS