TY - DATA T1 - Quantitative dynamic models describing erythropoetin signaling used as examples. PY - 2013/09/30 AU - Andreas Raue AU - Marcel Schilling AU - Julie Bachmann AU - Andrew Matteson AU - Max Schelke AU - Daniel Kaschek AU - Sabine Hug AU - Clemens Kreutz AU - Brian D. Harms AU - Fabian J. Theis AU - Ursula Klingmüller AU - Jens Timmer UR - https://plos.figshare.com/articles/figure/_Quantitative_dynamic_models_describing_erythropoetin_signaling_used_as_examples_/811089 DO - 10.1371/journal.pone.0074335.g001 L4 - https://ndownloader.figshare.com/files/1219760 KW - describing KW - erythropoetin N2 - The hormone erythropoietin (Epo) is the key regulator of erythropoiesis, the production of red blood cells. (a) Epo receptor model [2]. The model describes the interaction and the trafficking of the hormone and of its membrane receptor (EpoR). The active complex Epo_EpoR can be internalized (Epo_EpoR) and is either recycled back to the cell membrane or is degraded (dEpo, dEpo). (b) Model of Epo induced JAK2/STAT5 signaling [7]. In erythroid progenitor cells (CFU-E), the hormone Epo induces activation of the tyrosine kinase Janus kinase 2 (JAK2). Subsequently, the signal transducer and activator of transcription 5 protein (STAT5) is activated and shuttles to the nucleus where it induces target gene expression. Two of the target genes encode for the negative feedback regulators suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible SH2-containing protein (CIS). ER -