Rapid habituation of a touch-induced escape response in Zebrafish (<i>Danio rerio</i>) Larvae C. RobertsAdam ChornakJulia AlzagatitiJoseph B. LyDuy T. R. BillBrent TrinkellerJanie PearceKaycey C. ChoeRonny C. CampbellC. S. WongDustin DeutschEmily HernandezSarah L. GlanzmanDavid 2019 <div><p>Zebrafish larvae have several biological features that make them useful for cellular investigations of the mechanisms underlying learning and memory. Of particular interest in this regard is a rapid escape, or startle, reflex possessed by zebrafish larvae; this reflex, the C-start, is mediated by a relatively simple neuronal circuit and exhibits habituation, a non-associative form of learning. Here we demonstrate a rapid form of habituation of the C-start to touch that resembles the previously reported rapid habituation induced by auditory or vibrational stimuli. We also show that touch-induced habituation exhibits input specificity. This work sets the stage for <i>in vivo</i> optical investigations of the cellular sites of plasticity that mediate habituation of the C-start in the larval zebrafish.</p></div>