TY - DATA T1 - Arrhythmia susceptibility after chronic β-adrenergic stimulation-induced cardiac hypertrophy. PY - 2013/08/30 AU - Christina Westphal AU - Bastian Spallek AU - Anne Konkel AU - Lajos Marko AU - Fatimunnisa Qadri AU - Laura M. DeGraff AU - Carola Schubert AU - J. Alyce Bradbury AU - Vera Regitz-Zagrosek AU - John R. Falck AU - Darryl C. Zeldin AU - Dominik N. Müller AU - Wolf-Hagen Schunck AU - Robert Fischer UR - https://plos.figshare.com/articles/figure/_Arrhythmia_susceptibility_after_chronic_946_adrenergic_stimulation_induced_cardiac_hypertrophy_/785668 DO - 10.1371/journal.pone.0073490.g005 L4 - https://ndownloader.figshare.com/files/1186908 KW - Anatomy and physiology KW - electrophysiology KW - Biochemistry KW - lipids KW - Lipid mediators KW - genetics KW - gene expression KW - histology KW - Model organisms KW - Animal models KW - mouse KW - cardiovascular KW - arrhythmias KW - Heart failure KW - susceptibility KW - stimulation-induced KW - cardiac N2 - (A) Representative original tracings showing the induction of atrial fibrillation by programmed electrical stimulation in WT mice 2 weeks after chronic ISO infusion (upper panel) and the resistance of CYP2J2-TG mice treated in the same manner (lower panel). (B) Atrial fibrillation inducibility significantly increased in WT mice after chronic ISO infusion (n = 9) compared with the vehicle control (n = 8) and was significantly higher than in CYP2J2-TG mice (n = 7 and n = 8 for the vehicle and ISO groups). (C) The relative percentage of inducible sustained atrial fibrillation was markedly higher in WT compared with CYP2J2-TG after chronic ISO infusion. For statistical evaluation of arrhythmia inducibilities and severity scoring compare Fig. 2. Results represent mean±SEM; ANOVA, Post-Hoc Tukey; *p<0.05 vs. WT+Vehicle; †p<0.05 vs. CYP+Vehicle; ‡p<0.05 vs. WT+ISO. ER -