TY - DATA T1 - Effects of IL-13 deficiency in DSS-induced colitis. PY - 2013/08/28 AU - Md. Sharif Shajib AU - Huaqing Wang AU - Janice J. Kim AU - Ivana Sunjic AU - Jean-Eric Ghia AU - Emmanuel Denou AU - Matthew Collins AU - Judah A. Denburg AU - Waliul I. Khan UR - https://plos.figshare.com/articles/figure/_Effects_of_IL_13_deficiency_in_DSS_induced_colitis_/783110 DO - 10.1371/journal.pone.0072774.g001 L4 - https://ndownloader.figshare.com/files/1183524 KW - histology KW - immunology KW - Immune cells KW - monocytes KW - Immune system KW - cytokines KW - immunity KW - inflammation KW - Immune response KW - Model organisms KW - Animal models KW - mouse KW - Gastroenterology and hepatology KW - Inflammatory bowel disease KW - ulcerative colitis KW - il-13 KW - deficiency KW - dss-induced N2 - WT and IL-13−/− mice were administered 5% DSS in drinking water to induce colitis. Control mice received water without DSS. (A) Colonic IL-13 levels in WT mice with or without DSS. (B) Disease activity index (DAI). (C) Macroscopic damage score in DSS-induced colitis on day 5 after DSS induced colitis and in mice without colitis. (D) Histological damage assessment on day 5 post-DSS administration. (i) And (ii) Light micrograph of H&E-stained colonic section. DAI data represented as mean ± SEM from 5 mice per group; *represents statistical significance where p<0.05; # significantly lower disease activity in IL-13−/− mice receiving DSS compared to WT mice receiving DSS. ER -