10.1371/journal.pone.0072675.g001
Günther Zick
Günther
Zick
Gunnar Elke
Gunnar
Elke
Tobias Becher
Tobias
Becher
Dirk Schädler
Dirk
Schädler
Sven Pulletz
Sven
Pulletz
Sandra Freitag-Wolf
Sandra
Freitag-Wolf
Norbert Weiler
Norbert
Weiler
Inéz Frerichs
Inéz
Frerichs
Study flowchart.
Public Library of Science
2013
Anatomy and physiology
Respiratory system
Model organisms
Animal models
anesthesiology
Anesthesiology monitoring
Critical care and emergency medicine
Respiratory failure
Ventilatory support
Pulmonology
radiology
Diagnostic radiology
2013-08-22 02:25:22
Figure
https://plos.figshare.com/articles/figure/_Study_flowchart_/780434
<p>Ten animals were studied during volume-controlled ventilation during ventilation with 5 ml/kg (baseline) and 10 ml/kg tidal volume (V<sub>T</sub>) (measurement time point 1) in the normal lung (NL) as well as after induction of acute lung injury (ALI) (time point 2) at inspired fractions of oxygen of 0.5 and 1.0, respectively. Then a constant low-flow inflation maneuver (pressure-volume (PV) maneuver) was performed and positive end-expiratory pressure (PEEP) was set 2 cm H<sub>2</sub>O above the lower inflection point (LIP) identified in the PV curve. Using a crossover design, further measurements were performed 5 and 30 min after ventilation with low V<sub>T</sub> and active interventional lung assist (ILA) and after another 5 and 30 min with high V<sub>T</sub> and inactive ILA (no ILA) (time points 3–6). Five animals were randomly ventilated in the reversed chronological order. Ventilator settings of V<sub>T</sub> and PEEP at each measurement time point are shown in the lower part of the Figure. *, time elapsed after the change in ventilator and ILA settings.</p>