microRNA-21 expression in the PDAC stroma is associated with poor prognosis.
Brian E. Kadera
Luyi Li
Paul A. Toste
Nanping Wu
Curtis Adams
David W. Dawson
Timothy R. Donahue
10.1371/journal.pone.0071978.g001
https://plos.figshare.com/articles/figure/_microRNA_21_expression_in_the_PDAC_stroma_is_associated_with_poor_prognosis_/780420
<p>(<b>A</b>) Representative images of histoscores for miR-21 <i>in situ</i> hybridization in PDAC tumor cells and stroma. These two cellular compartments were scored as 0 negative (not depicted), 1 weakly positive, 2 moderately positive, 3 strongly positive. (<b>B</b>) Kaplan-Meier analysis reveals that high miR-21 stromal expression is associated with decreased overall survival (P = 0.04). miR-21 expression intensity was dichotomized into high (n = 73) vs. low (n = 72) based on the median score of all tumors.</p>
2013-08-22 02:24:05
genetics
epigenetics
RNA interference
Molecular cell biology
Cellular types
Connective tissue cells
gene expression
oncology
Basic cancer research
metastasis
Cancer treatment
Epigenetic therapy
Cancers and neoplasms
Gastrointestinal tumors
Pancreatic cancer
pdac
stroma