microRNA-21 expression in the PDAC stroma is associated with poor prognosis. Brian E. Kadera Luyi Li Paul A. Toste Nanping Wu Curtis Adams David W. Dawson Timothy R. Donahue 10.1371/journal.pone.0071978.g001 https://plos.figshare.com/articles/figure/_microRNA_21_expression_in_the_PDAC_stroma_is_associated_with_poor_prognosis_/780420 <p>(<b>A</b>) Representative images of histoscores for miR-21 <i>in situ</i> hybridization in PDAC tumor cells and stroma. These two cellular compartments were scored as 0 negative (not depicted), 1 weakly positive, 2 moderately positive, 3 strongly positive. (<b>B</b>) Kaplan-Meier analysis reveals that high miR-21 stromal expression is associated with decreased overall survival (P = 0.04). miR-21 expression intensity was dichotomized into high (n = 73) vs. low (n = 72) based on the median score of all tumors.</p> 2013-08-22 02:24:05 genetics epigenetics RNA interference Molecular cell biology Cellular types Connective tissue cells gene expression oncology Basic cancer research metastasis Cancer treatment Epigenetic therapy Cancers and neoplasms Gastrointestinal tumors Pancreatic cancer pdac stroma