%0 Figure %A Costa, Barbara %A Bendinelli, Sara %A Gabelloni, Pamela %A Pozzo, Eleonora Da %A Daniele, Simona %A Scatena, Fabrizio %A Vanacore, Renato %A Campiglia, Pietro %A Bertamino, Alessia %A Gomez-Monterrey, Isabel %A Sorriento, Daniela %A Del Giudice, Carmine %A Iaccarino, Guido %A Novellino, Ettore %A Martini, Claudia %D 2013 %T siRNA against p21 made ISA27 unable to induce ΔΨm dissipation and PE. %U https://plos.figshare.com/articles/figure/_siRNA_against_p21_made_ISA27_unable_to_induce_916_936_m_dissipation_and_PE_/776379 %R 10.1371/journal.pone.0072281.g013 %2 https://ndownloader.figshare.com/files/1174878 %K Biochemistry %K drug discovery %K Small molecules %K Molecular cell biology %K Cell death %K Drugs and devices %K Drug research and development %K oncology %K Cancers and neoplasms %K Neurological tumors %K Glioblastoma multiforme %K Basic cancer research %K p21 %K isa27 %K induce %K dissipation %X

Random siRNA and p21siRNA samples were exposed to a fixed dose of ISA27 (5 µM) or DMSO for 24 h. A) Evaluation of ISA27 effect on the ΔΨm in p21 siRNA samples. The ISA27-treated random siRNA sample showed dissipation of ΔΨm compared to random siRNA sample. The comparison of ΔΨm between p21 siRNA and ISA27-treated p21 siRNA sample did not show statistically significant differences. Upper panel shows representative dot plots of untreated and ISA27-treated random or p21siRNA samples. B) Evaluation of ISA27 effect on PE in p21 siRNA samples. The ISA27-treated random siRNA sample showed a statistical significant increase of early and late apoptosis compared to random siRNA sample. The comparison of early and late apoptosis between p21 siRNA and ISA27-treated p21 siRNA sample did not show statistically significant differences.

%I PLOS ONE